Glycerin Guaiacolate
3-(2-Methoxyphenoxy)-1,2-propanediol
CAS: 93-14-1
Molecular Formula: C10H14O4
Glycerin Guaiacolate - Names and Identifiers
| Name | 3-(2-Methoxyphenoxy)-1,2-propanediol |
| Synonyms | 2-G Guaifenesin Glycerol guaiacolate Glycerin Guaiacolate Guaiacol Glycerol Ether 3-(2-methoxyphenoxy)-2-propanediol 3-(o-methoxyphenoxy)-2-propanediol 3-(2-Methoxyphenosy)-1,2-propamediol 3-(2-Methoxyphenoxy)-1,2-propanediol 1,2-Propanediol, 3-(o-methoxyphenoxy)- 1,2-Propanediol, 3-(2-methoxyphenoxy)- 1,2-Dihydroxy-3-(2-methoxyphenoxy)propane |
| CAS | 93-14-1 |
| EINECS | 202-222-5 |
| InChI | InChI=1/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3/t8-/m0/s1 |
| InChIKey | HSRJKNPTNIJEKV-UHFFFAOYSA-N |
Glycerin Guaiacolate - Physico-chemical Properties
| Molecular Formula | C10H14O4 |
| Molar Mass | 198.22 |
| Density | 1.1825 (rough estimate) |
| Melting Point | 77-81 °C |
| Boling Point | 215 °C (19 mmHg) |
| Flash Point | 215°C/19mm |
| Water Solubility | 5 g/100 mL (25 ºC) |
| Solubility | DMSO : 100 mg/mL (504.49 mM; Need ultrasonic and warming) |
| Vapor Presure | 1.04E-05mmHg at 25°C |
| Appearance | White to off-white (Solid) |
| Color | White to Off-White |
| Merck | 14,4555 |
| BRN | 2049375 |
| pKa | 13.53±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.5550 (estimate) |
| MDL | MFCD00016873 |
| Physical and Chemical Properties | Melting point 77-81°C boiling point 215°C (19 mmHg) water-soluble 5g/100 mL (25°C) |
| Use | Expectorant antitussive, suitable for phlegm cough chronic bronchitis, bronchiectasis and other diseases |
Glycerin Guaiacolate - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 1 |
| RTECS | TY8400000 |
| TSCA | Yes |
| HS Code | 29093090 |
| Hazard Note | Harmful |
| Toxicity | LD50 oral in rabbit: 2553mg/kg |
Glycerin Guaiacolate - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| expectorant drug | guaiphenesin is also known as dimethoxyphenyl ether, guaifenesin, guaifenesin, guaifenesin, it is an irritant expectorant, which can stimulate the gastric mucosa after oral administration, and increase the secretion of bronchial mucosal glands, reduce the viscosity of sputum, and make the phlegm easy to cough up. Suitable for the treatment of phlegm is not easy to cough. Guaiphenesin has a Disinfection antiseptic effect, can reduce the stench of sputum, but also has antitussive, antispasmodic, anticonvulsant effect, for chronic bronchitis, sputum Cough, lung abscess, bronchiectasis and secondary asthma, it is used in combination with other antitussive and Antiasthmatic drugs. Can be absorbed from the gastrointestinal tract, and in 1 to 3 hours to reach the peak blood concentration. Most of them were excreted from the intestine, and a small amount of glucuronic acid conjugates were rapidly excreted with urine. |
| Use | guaiphenesin is an expectorant antitussive drug, suitable for chronic bronchitis, bronchiectasis and other diseases. |
| production method | results from the condensation of sodium guaiacolate with 3-chloropropanediol. Sodium hydroxide solution and guaiacol were prepared into sodium phenolate at 40 ℃, 3-chloro-1, 2-propanediol was added, the temperature was raised to 95 ℃, and the mixture was allowed to stand at 92-98 ℃ for 3 hours, the brine layer was separated and acidified to pH 3-5 by addition of hydrochloric acid. The crystals were cooled and filtered. The filter cake was recrystallized from ethanol to obtain guaiphenesin. The yield was about 60%. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
Supplier List
Featured ProductsSpot supply
Product Name: Guaiacol Glycerol Ether Visit Supplier Webpage Request for quotationCAS: 93-14-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Guaifenesin Request for quotationCAS: 93-14-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Guaifenesin Visit Supplier Webpage Request for quotationCAS: 93-14-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Guaifenesin (Standard) Visit Supplier Webpage Request for quotationCAS: 93-14-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 3-(2-Methoxyphenoxy)-12-propanediol99+ Visit Supplier Webpage Request for quotationCAS: 93-14-1
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: 3-(2-Methoxyphenoxy)-1,2-propanediol Request for quotation
CAS: 93-14-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 93-14-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Guaifenesin Visit Supplier Webpage Request for quotationCAS: 93-14-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Featured ProductsSpot supply
Product Name: Guaiacol Glycerol Ether Visit Supplier Webpage Request for quotationCAS: 93-14-1
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Multiple SpecificationsSpot supply
Product Name: Guaifenesin Request for quotationCAS: 93-14-1
Tel: 400-968-2212
Email: 3623107365@qq.com
Mobile: 18916960931
QQ: 3623107365
Wechat: 18916960931
Spot supply
Product Name: Guaifenesin Visit Supplier Webpage Request for quotationCAS: 93-14-1
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Multiple SpecificationsSpot supply
Product Name: Guaifenesin (Standard) Visit Supplier Webpage Request for quotationCAS: 93-14-1
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 3-(2-Methoxyphenoxy)-12-propanediol99+ Visit Supplier Webpage Request for quotationCAS: 93-14-1
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Product Name: 3-(2-Methoxyphenoxy)-1,2-propanediol Request for quotation
CAS: 93-14-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 93-14-1
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Guaifenesin Visit Supplier Webpage Request for quotationCAS: 93-14-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History